News Release Details
Phio Pharmaceuticals Initiates In Vivo Studies of INTASYL Based Antivirals Against SARS-CoV-2
Novel drugs designed using the INTASYL technology provide an efficient hit to lead process by bioinformatics-based drug design using a proprietary algorithm. This process requires the design of ~20 compounds for a single target which can then be screened to provide a lead compound for optimization. The INTASYL antiviral compounds being studied to treat SARS-CoV-2 infection are designed against three targets, including two virus-related targets and one novel host-related target. These compounds were tested and activity confirmed in laboratory tests with two different in vitro models of SARS-CoV-2 infection at two independent laboratories. Based on these in vitro data, three compounds, one per target, have been selected for further in vivo testing.
"The rapid identification of lead compounds for testing in this validated in vivo model of SARS-CoV-2 infection highlights the efficiency and flexibility of the INTASYL platform," said Dr.
"Gene silencing represents a promising antiviral development strategy," added
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Ashley R. Robinson